Reactive oxygen intermediate(s) (ROI): common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis.

@article{MCGOWAN1996ReactiveOI,
  title={Reactive oxygen intermediate(s) (ROI): common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis.},
  author={ANNA J. MCGOWAN and Mar{\'i}a del Carmen Ruiz-Ruiz and Adrienne M Gorman and Abelardo L{\'o}pez-Rivas and Thomas G Cotter},
  journal={FEBS letters},
  year={1996},
  volume={392 3},
  pages={299-303}
}
HL-60 acute myeloblastic and U937 monoblastoid leukaemic cell lines both cleave poly(ADP-ribose)polymerase (PARP), at the onset of apoptosis, in response to a wide range of cytotoxic agents. This appears to be a common feature of leukaemic cell apoptosis. However, in the chronic myelogenous leukaemic (CML) derived cell line, K562, no such cleavage was detectable. This correlated with previous findings that this cell line is particularly resistant to apoptosis induced by cytotoxic agents… CONTINUE READING

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