Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction

@inproceedings{Singer2012ReactiveOA,
  title={Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction},
  author={Georg Singer and Karen Y. Stokes and D. Neil Granger},
  booktitle={Inflammation Research},
  year={2012}
}
Hepatic microvascular dysfunction is a critical event in the development of liver failure during sepsis. Activated blood cells and reactive oxygen and nitrogen species (RONS) have been implicated in the pathogenesis of sepsis. Intravital-videomicroscopy was used to determine whether RONS contribute to the recruitment of leukocytes/platelets in the hepatic microvasculature during sepsis. Six hours following cecal-ligation and puncture (CLP), disturbances of the hepatic microvasculature were… CONTINUE READING