Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease.

@article{Przedborski2005ReactiveOA,
  title={Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease.},
  author={Serge E. Przedborski and Harry Ischiropoulos},
  journal={Antioxidants & redox signaling},
  year={2005},
  volume={7 5-6},
  pages={685-93}
}
Parkinson's disease (PD) is a common neurodegenerative disease whose etiology and pathogenesis remain mainly unknown. To investigate its cause and, more particularly, its mechanism of neuronal death, numerous in vivo experimental models have been developed. Currently, both genetic and toxic models of PD are available, but the use of neurotoxins such as 6-hydroxydopamine, paraquat, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and rotenone are still the most popular means for modeling the… CONTINUE READING