Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases

  title={Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases},
  author={M. Ramalingam and S. Kim},
  journal={Journal of Neural Transmission},
  • M. Ramalingam, S. Kim
  • Published 2011
  • Medicine, Biology
  • Journal of Neural Transmission
  • The continuous production and efflux of reactive oxygen/nitrogen species from endogenous and exogenous sources can damage biological molecules and initiate a cascade of events. Mitochondria are pivotal in controlling cell survival and death. Cumulative oxidative stress, disrupted mitochondrial respiration, and mitochondrial damage are related with various neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and others. Biochemical cascades of apoptosis are mediated… CONTINUE READING
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    • 16
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    Publications referenced by this paper.
    Neurodegenerative diseases and oxidative stress.
    • 607
    • Highly Influential
    Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival
    • 324
    4-hydroxynonenal and neurodegenerative diseases.
    • 265
    Oxidative stress signalling in Alzheimer's disease
    • 366
    • Highly Influential
    Free radical pathways in CNS injury.
    • 723
    Oxidative stress and neuronal death/survival signaling in cerebral ischemia
    • 184
    Cellular mechanisms of resistance to chronic oxidative stress.
    • 171
    • Highly Influential
    Oxidative stress: Free radical production in neural degeneration
    • 401
    Modeling oxidative stress in the central nervous system.
    • 31
    • Highly Influential
    • PDF