Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases

@article{Ramalingam2011ReactiveOS,
  title={Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases},
  author={M. Ramalingam and Sung-jin Kim},
  journal={Journal of Neural Transmission},
  year={2011},
  volume={119},
  pages={891-910}
}
The continuous production and efflux of reactive oxygen/nitrogen species from endogenous and exogenous sources can damage biological molecules and initiate a cascade of events. Mitochondria are pivotal in controlling cell survival and death. Cumulative oxidative stress, disrupted mitochondrial respiration, and mitochondrial damage are related with various neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and others. Biochemical cascades of apoptosis are mediated… Expand
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