Reactive nitrogen species reactivities with nitrones: theoretical and experimental studies.

@article{Nash2012ReactiveNS,
  title={Reactive nitrogen species reactivities with nitrones: theoretical and experimental studies.},
  author={Kevin M. Nash and Antal Rockenbauer and Frederick A. Villamena},
  journal={Chemical research in toxicology},
  year={2012},
  volume={25 8},
  pages={1581-97}
}
Reactive nitrogen species (RNS) such as nitrogen dioxide ((•)NO(2)), peroxynitrite (ONOO(-)), and nitrosoperoxycarbonate (ONOOCO(2)(-)) are among the most damaging species present in biological systems due to their ability to cause modification of key biomolecular systems through oxidation, nitrosylation, and nitration. Nitrone spin traps are known to react with free radicals and nonradicals via electrophilic and nucleophilic addition reactions and have been employed as reagents to detect… CONTINUE READING

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