Reactive microglia in Creutzfeldt-Jakob disease.

  title={Reactive microglia in Creutzfeldt-Jakob disease.},
  author={H M{\"u}hleisen and Jochen Gehrmann and Richard Meyermann},
  journal={Neuropathology and applied neurobiology},
  volume={21 6},
Creutzfeldt-Jakob disease (CJD) is characterized by a loss of neurons accompanied by astrogliosis and spongiform changes in the neuropil. It has been recognized that reactive microglia occur in CJD but little is known about the regional distribution and extent of the microglial activation. We have, therefore, examined six brains from cases of sporadic CJD by immunohistochemical labelling of grey and white matter microglia from frontal, parietal, temporal, and occipital lobes, striatum, thalamus… CONTINUE READING


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