Reactive immunization suppresses advanced glycation and mitigates diabetic nephropathy.

@article{Shcheglova2009ReactiveIS,
  title={Reactive immunization suppresses advanced glycation and mitigates diabetic nephropathy.},
  author={Tatiana Shcheglova and Sudesh Paul Makker and Alfonso Tramontano},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2009},
  volume={20 5},
  pages={1012-9}
}
Agents that inhibit glycation end products by reducing the carbonyl load from glycation and glycoxidation are an emerging pharmacologic approach to treat complications of diabetes. We previously demonstrated that antibodies generated to the glycoprotein keyhole limpet hemocyanin (KLH) can cross-link with reactive carbonyl residues on protein conjugates. Here, we immunized streptozotocin-induced diabetic rats with KLH to assess the capacity of the elicited antibodies to intercept carbonyl… CONTINUE READING