Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition.

@article{Mooser1990ReactiveHI,
  title={Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition.},
  author={Vincent E. Mooser and Juerg Nussberger and Lucienne Juillerat and Michel Burnier and Bernard Waeber and J Bidiville and Nicolas Pauly and Hans Rudolf Brunner},
  journal={Journal of cardiovascular pharmacology},
  year={1990},
  volume={15 2},
  pages={276-82}
}
The new ACE inhibitor trandolapril was administered to normal volunteers at daily doses of 0.5, 2, and 8 mg for 10 days. Twenty-one volunteers, aged 21-30 years, were included in the study. To randomly selected groups of seven subjects, each dose was administered in a single-blind fashion. None of the doses induced a consistent fall in blood pressure. Angiotensin-converting enzyme activity (ACE) was measured in vitro using three different synthetic substrates (i.e., Hip-Gly-Gly, Z-Phe-His-Leu… CONTINUE READING

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