Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice.


Gliosis is a characteristic pathologic state in many CNS disorders. Cytokines are considered to be effectors of gliosis. In order to explore the role of IL-6 in gliosis, the temporal and spatial expression of the IL-6 gene and its consequent effects on the brain were studied in a GFAP-IL6 transgenic mouse model. In GFAP-IL6 mice, IL-6 transgene expression… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.