Reactive disulfide bonds in immunoglobulin G. A unique feature in serum proteins of different species.

@article{Schauenstein1996ReactiveDB,
  title={Reactive disulfide bonds in immunoglobulin G. A unique feature in serum proteins of different species.},
  author={E. Schauenstein and Konrad Schauenstein and F Dachs and Manfred Reiter and A. Leitsberger and M. Weblacher and K Maninger and H Horejsi and W. Steinschifter and Christian Bernd Hirschmann and P. Felsner},
  journal={Biochemistry and molecular biology international},
  year={1996},
  volume={40 3},
  pages={433-46}
}
A reactive disulfide bond (SS)* was detected and characterized in IgG of humans, rats and mice by virtue of disulfide interchange with dithionitrobenzoate. (SS)* was found exclusively in human IgG1 and rat IgG2b. In human IgG1 (SS)* was identified as the upper one of the two interheavy bridges in the hinge, where it appears to take part in complement activation. The biological significance of (SS)* in IgG was underlined by the fact that no other serum proteins were found to exhibit a similar… CONTINUE READING

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