Reactive changes of retinal microglia during fatal murine cerebral malaria: effects of dexamethasone and experimental permeabilization of the blood-brain barrier.

@article{Medana2000ReactiveCO,
  title={Reactive changes of retinal microglia during fatal murine cerebral malaria: effects of dexamethasone and experimental permeabilization of the blood-brain barrier.},
  author={Isabelle M. Medana and Tailoi Chan-Ling and Nicholas Henry Hunt},
  journal={The American journal of pathology},
  year={2000},
  volume={156 3},
  pages={1055-65}
}
Microglial activation and redistribution toward blood vessels are some of the earliest observable events occurring within the central nervous system (CNS) during fatal murine cerebral malaria (FMCM). To investigate stimuli that might modulate microglial reactivity during FMCM we have performed two experimental manipulations and observed microglial responses in retinal whole mounts. First, to determine whether increased blood-brain barrier (BBB) permeability in the absence of the malaria… CONTINUE READING