Reactive carbonyl compounds related uremic toxicity ("carbonyl stress").

  title={Reactive carbonyl compounds related uremic toxicity ("carbonyl stress").},
  author={Toshio Miyata and Satoshi Sugiyama and Akira Saito and Kiyoshi Kurokawa},
  journal={Kidney international. Supplement},
Many studies on uremic toxins have focused on enzymatic biochemistry. Recently, attention has turned to nonenzymatic biochemistry, especially progressive and irreversible modifications of proteins. Two different approaches opened the field of irreversible nonenzymatic modifications of proteins in uremia: the advanced glycation end products (AGEs) derived from the Maillard reaction and the advanced lipoxidation end products (ALEs) derived from lipid peroxidation. They have revealed the… CONTINUE READING