Reactive astrogliosis induces astrocytic differentiation of adult neural stem/progenitor cells in vitro.

@article{Faijerson2006ReactiveAI,
  title={Reactive astrogliosis induces astrocytic differentiation of adult neural stem/progenitor cells in vitro.},
  author={Jonas Faijerson and Rogan B Tinsley and Karina Apric{\'o} and Annika Thorsell and Christina Nodin and Michael J Nilsson and Fredrik Blomstrand and Peter S. Eriksson},
  journal={Journal of neuroscience research},
  year={2006},
  volume={84 7},
  pages={1415-24}
}
Neural stem cells reside in defined areas of the adult mammalian brain, including the dentate gyrus of the hippocampus. Rat neural stem/progenitor cells (NSPCs) isolated from this region retain their multipotency in vitro and in vivo after grafting into the adult brain. Recent studies have shown that endogenous or grafted NSPCs are activated after an injury and migrate toward lesioned areas. In these areas, reactive astrocytes are present and secrete numerous molecules and growth factors… CONTINUE READING

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