Reactive astrocytes secrete lcn2 to promote neuron death.

  title={Reactive astrocytes secrete lcn2 to promote neuron death.},
  author={Fangfang Bi and Cao Huang and Jianbin Tong and Guang Qiu and Bo Huang and Qinxue Wu and Fang Li and Zuoshang Xu and Robert Bowser and Xu-Gang Xia and Hongxia Zhou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 10},
Glial reaction is a common feature of neurodegenerative diseases. Recent studies have suggested that reactive astrocytes gain neurotoxic properties, but exactly how reactive astrocytes contribute to neurotoxicity remains to be determined. Here, we identify lipocalin 2 (lcn2) as an inducible factor that is secreted by reactive astrocytes and that is selectively toxic to neurons. We show that lcn2 is induced in reactive astrocytes in transgenic rats with neuronal expression of mutant human TAR… CONTINUE READING
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