Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain

@article{Xing2013ReactiveAP,
  title={Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain},
  author={F. Xing and A. Kobayashi and H. Okuda and M. Watabe and S. K. Pai and P. R. Pandey and S. Hirota and A. Wilber and Y. Mo and B. Moore and Wen Liu and K. Fukuda and Megumi Iiizumi and Sambad Sharma and Yin Liu and Kerui Wu and E. Peralta and K. Watabe},
  journal={EMBO Molecular Medicine},
  year={2013},
  volume={5},
  pages={384 - 396}
}
Brain metastasis of breast cancer profoundly affects the cognitive and sensory functions as well as morbidity of patients, and the 1 year survival rate among these patients remains less than 20%. However, the pathological mechanism of brain metastasis is as yet poorly understood. In this report, we found that metastatic breast tumour cells in the brain highly expressed IL‐1β which then ‘activated’ surrounding astrocytes. This activation significantly augmented the expression of JAG1 in the… Expand
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Adrenergic signaling promotes angiogenesis through endothelial cell-tumor cell crosstalk.
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