Reactive Oxygen Species-induced Oxidative Stress in the Development of Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome

@article{Gonzlez2006ReactiveOS,
  title={Reactive Oxygen Species-induced Oxidative Stress in the Development of Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome},
  author={F. Baigorri Gonz{\'a}lez and Neal S. Rote and Judi Minium and John P Kirwan},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 1},
  pages={336-40}
}
CONTEXT Insulin resistance and chronic low level inflammation are often present in women with polycystic ovary syndrome (PCOS). OBJECTIVE The purpose of this study was to determine the effects of hyperglycemia on reactive oxygen species (ROS) generation from mononuclear cells (MNCs) in PCOS. DESIGN This was a prospective controlled study. SETTING The study was conducted at an academic medical center. PATIENTS The study population consisted of 16 women with PCOS (eight lean, eight obese… CONTINUE READING

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