Reactive Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the Treatment of Gallstones with Melatonin: A Review

@article{Koppisetti2007ReactiveOS,
  title={Reactive Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the Treatment of Gallstones with Melatonin: A Review},
  author={Sreedevi Koppisetti and Bharat Jenigiri and Mar{\'i}a Pilar Terr{\'o}n and Sandra Tengattini and Hiroshi Tamura and Luis J. Flores and Dun-Xian Tan and Russel Joseph Reiter},
  journal={Digestive Diseases and Sciences},
  year={2007},
  volume={53},
  pages={2592-2603}
}
Free radical-mediated damage of the gall bladder epithelium predisposes to the development of both gall bladder inflammation and gallstone formation, which often coexist. Melatonin, a pineal and gut secretory product, due to its antioxidant activity along with its effect on the aging gall bladder myocytes, inhibits gallstone formation. Melatonin reduces the biliary levels of cholesterol by inhibiting cholesterol absorption across the intestinal epithelium and by increasing the conversion of… 

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