Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis

  title={Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis},
  author={Maria de F{\'a}tima Horta and B{\'a}rbara Pinheiro Mendes and Eric Henrique Roma and F{\'a}tima Soares Motta Noronha and Juan Pereira Mac{\^e}do and Luciana Souza Oliveira and Myrian Morato Duarte and Leda Qu{\'e}rcia Vieira},
  booktitle={Journal of parasitology research},
Cutaneous leishmaniasis affects millions of people around the world. Several species of Leishmania infect mouse strains, and murine models closely reproduce the cutaneous lesions caused by the parasite in humans. Mouse models have enabled studies on the pathogenesis and effector mechanisms of host resistance to infection. Here, we review the role of nitric oxide (NO), reactive oxygen species (ROS), and peroxynitrite (ONOO(-)) in the control of parasites by macrophages, which are both the host… CONTINUE READING