Reactive Oxygen Species and Colorectal Cancer.

  title={Reactive Oxygen Species and Colorectal Cancer.},
  author={Sandeep Sreevalsan and Stephen Safe},
  journal={Current colorectal cancer reports},
  volume={9 4},
Several agents used for treatment of colon and other cancers induce reactive oxygen species (ROS) and this plays an important role in their anticancer activities. In addition to the well-known proapoptotic effects of ROS inducers, these compounds also decrease expression of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and several pro-oncogenic Spregulated genes important for cancer cell proliferation, survival and metastasis. The mechanism of these responses involve ROS… CONTINUE READING
Highly Cited
This paper has 908 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 20 extracted citations

909 Citations

Citations per Year
Semantic Scholar estimates that this publication has 909 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…