Reactive Oxygen Species and Colorectal Cancer.

@article{Sreevalsan2013ReactiveOS,
  title={Reactive Oxygen Species and Colorectal Cancer.},
  author={Sandeep Sreevalsan and Stephen Safe},
  journal={Current colorectal cancer reports},
  year={2013},
  volume={9 4},
  pages={350-357}
}
Several agents used for treatment of colon and other cancers induce reactive oxygen species (ROS) and this plays an important role in their anticancer activities. In addition to the well-known proapoptotic effects of ROS inducers, these compounds also decrease expression of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and several pro-oncogenic Spregulated genes important for cancer cell proliferation, survival and metastasis. The mechanism of these responses involve ROS… CONTINUE READING
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