Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin

  title={Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin},
  author={Russel J. Reiter and Josep M. Guerrero and Joaqu{\'i}n J. Garc{\'i}a and Dar{\'i}o Acu{\~n}a-Castroviejo},
  journal={Annals of the New York Academy of Sciences},
ABSTRACT: Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger and indirect antioxidant. In terms of its scavenging activity, melatonin has been shown to quench the hydroxyl radical, superoxide anion radical, singlet oxygen, peroxyl radical, and the peroxynitrite anion. Additionally, melatonin's antioxidant actions probably derive from its stimulatory effect on superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose‐6‐phosphate… 

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Oxidative processes and antioxidative defense mechanisms in the aging brain 1

  • R. Reiter
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1995
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Oxygen free radicals, melatonin, and aging

Characterization of the antioxidant effects of melatonin and related indoleamines in vitro

An antiperoxidative and antioxidant action of melatonin which is devoid of pro‐oxidant effect on non‐lipid substrates is supported.

Melatonin protects neurons from singlet oxygen‐induced apoptosis

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