Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin

@article{Reiter1998ReactiveOI,
  title={Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin},
  author={Russel J. Reiter and Josep M. Guerrero and Joaqu{\'i}n J. Garc{\'i}a and Dar{\'i}o Acu{\~n}a-Castroviejo},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={854}
}
ABSTRACT: Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger and indirect antioxidant. In terms of its scavenging activity, melatonin has been shown to quench the hydroxyl radical, superoxide anion radical, singlet oxygen, peroxyl radical, and the peroxynitrite anion. Additionally, melatonin's antioxidant actions probably derive from its stimulatory effect on superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose‐6‐phosphate… 

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