Reactive Lysis: the Complement-mediated Lysis of Unsensitized Cells

@article{Lachmann1970ReactiveLT,
  title={Reactive Lysis: the Complement-mediated Lysis of Unsensitized Cells},
  author={Peter J. Lachmann and Ronald A Thompson},
  journal={The Journal of Experimental Medicine},
  year={1970},
  volume={131},
  pages={643 - 657}
}
It has been shown that the "activated reactor" that is produced in certain human sera by complement activation is a stable complex of the fifth and sixth component of complement (C56). On interaction with C7, the indicator factor, a complex C567 is formed which for a short time (half-life less than 1 min) has an activated binding site and can attach itself to normal red cell membranes, conferring on them the hemolytic properties of the "heat stable" complement intermediate EC 1 approximately 7… CONTINUE READING