[Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes].

Abstract

Mono-quaternary salts Z have been prepared from pyridine-aldoximes and 1,3-dihalogen compounds. These were used to synthesize asymmetrical bis-quaternary pyridine-oximes with three-membered bridge. The effect of reactivation of phosphorylated AChE by these substances is less than that of obidoxim (Toxogonin).

Cite this paper

@article{Hagedorn1978ReactivationOP, title={[Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes].}, author={Ina Hagedorn and Imke Stark and Kathleen Schoene and Heide Schenkel}, journal={Arzneimittel-Forschung}, year={1978}, volume={28 11}, pages={2055-7} }