Reactivation of latent infection and induction of recurrent herpetic eye disease in mice.

  title={Reactivation of latent infection and induction of recurrent herpetic eye disease in mice.},
  author={Carolyn Shimeld and Terry J. Hill and William Blyth and David L. Easty},
  journal={The Journal of general virology},
  volume={71 ( Pt 2)},
During primary ocular infection of mice with herpes simplex virus type 1 (HSV-1) strain McKrae, dendritic corneal ulcers developed and many eyes became permanently damaged. When primary infection had subsided, latent infection was detected in the three parts of the trigeminal ganglion and in the superior cervical ganglion. Such latently infected mice were treated with cyclophosphamide, dexamethasone and u.v. irradiation, or cyclophosphamide and dexamethasone alone. After treatment with… CONTINUE READING


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