Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling.

@article{Fuller1999ReactivationOI,
  title={Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling.},
  author={Gregory N Fuller and Chang Hun Rhee and Kenneth R. Hess and Laura S. Caskey and Ruoxiang Wang and Janet M. Bruner and W. K. Alfred Yung and Wei Zhang},
  journal={Cancer research},
  year={1999},
  volume={59 17},
  pages={4228-32}
}
We carried out a gene expression profiling study using cDNA array technology with 24 primary glioma tissues of low-grade (oligodendroglioma), intermediate-grade (anaplastic oligodendroglioma and anaplastic astrocytoma), and high-grade (glioblastomas multiforme) tumors and found that insulin-like growth factor binding protein 2 (IGFBP2) was consistently overexpressed only in glioblastoma multiforme. The cDNA array results were confirmed by Northern and Western blotting. The fact that the IGFBP2… CONTINUE READING

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