Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium--oximes.

@article{Kuca2004ReactivationOC,
  title={Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium--oximes.},
  author={Kamil Kuca and Jiř{\'i} Pato{\vc}ka},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  year={2004},
  volume={19 1},
  pages={39-43}
}
Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which is resistant to conventional oxime therapy. To gain insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibited in vitro by cyclosarin (pH 8.0, 25 degrees C) and reactivated with 22 different pyridiniumoximes. Three… CONTINUE READING