Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 Gs homopolymer repeat of the thymidine kinase gene.

@article{Morfin2000ReactivationOA,
  title={Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 Gs homopolymer repeat of the thymidine kinase gene.},
  author={Florence Morfin and Danielle Thouvenot and Mich{\`e}le Aymard and G{\'e}rard Souillet},
  journal={Journal of medical virology},
  year={2000},
  volume={62 2},
  pages={
          247-50
        }
}
HSV infections are treated efficiently and prevented by acyclovir, although resistant strains have been reported. Resistance to acyclovir involves mainly mutations in the viral gene encoding thymidine kinase; mutations may lead to an altered or, more frequently, deficient TK. These acyclovir-resistant TK deficient strains are not able to reactivate from a latent infection in an experimental model, compared to TK positive strains. A case is reported of a bone marrow transplant child who… CONTINUE READING

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