Reactivation of a hematopoietic endocrine program of pregnancy contributes to recovery from thrombocytopenia.

@article{Bhattacharyya2002ReactivationOA,
  title={Reactivation of a hematopoietic endocrine program of pregnancy contributes to recovery from thrombocytopenia.},
  author={Sumit Bhattacharyya and Jiandie D. Lin and Daniel I. H. Linzer},
  journal={Molecular endocrinology},
  year={2002},
  volume={16 6},
  pages={
          1386-93
        }
}
Regulation of blood platelet levels involves an array of cytokines, including the placental hormone PRL-like protein E (PLP-E). The PLP-E receptor is present on megakaryocytes in pregnant mice, nonpregnant female mice, and male mice. Other known megakaryocytic cytokines do not share the PLP-E receptor, and thus the presence of this receptor in nonpregnant animals suggests that PLP-E may be expressed in tissues other than the placenta. Consistent with this prediction, PLP-E is produced in… CONTINUE READING

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