Reactivation of Recall-Induced Neurons in the Infralimbic Cortex and the Basolateral Amygdala After Remote Fear Memory Attenuation

@article{Khalaf2019ReactivationOR,
  title={Reactivation of Recall-Induced Neurons in the Infralimbic Cortex and the Basolateral Amygdala After Remote Fear Memory Attenuation},
  author={Ossama Khalaf and Johannes Gr{\"a}ff},
  journal={Frontiers in Molecular Neuroscience},
  year={2019},
  volume={12}
}
Whether the attenuation of traumatic memories is mediated through the suppression of the original memory trace of fear by a new memory trace of safety, or through an updating of the original fear trace towards safety has been a long-standing question at the interface of neuroscience and psychology. This matter is of particular importance for remote fear memories as they lie at the core of stress- and anxiety-related disorders. Recently, we have found that in the dentate gyrus, the effective… Expand
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References

SHOWING 1-10 OF 74 REFERENCES
Reactivation of recall-induced neurons contributes to remote fear memory attenuation
TLDR
It is found that effective remote fear attenuation is accompanied by the reactivation of memory recall–induced neurons in the dentate gyrus and that the continued activity of these neurons is critical for fear reduction, which suggests that the original memory trace of fear actively contributes to remoteFear attenuation. Expand
Dissociation of the Role of Infralimbic Cortex in Learning and Consolidation of Extinction of Recent and Remote Aversion Memory
TLDR
The data indicate that the IL is implicated in the extinction of fear and nonfear-based associations and suggest dissociation in the engagement of the IL in the learning and consolidation of food aversion extinction over time. Expand
Extinction after retrieval: effects on the associative and nonassociative components of remote contextual fear memory.
TLDR
It is shown that the reconsolidation-extinction procedure fails to prevent the spontaneous recovery of a remote contextual fear memory in a mouse model of PTSD, as well as the long-lasting behavioral abnormalities induced by traumatic experience on anxiety and in both social and cognitive domains. Expand
A cFos activation map of remote fear memory attenuation
TLDR
Results suggest that progressive fear attenuation mediated by repetitive exposure is accompanied by sustained neuronal activation and not reverted to a pre-conditioning brain state, and contribute to the identification of brain areas as targets for therapeutic approaches against traumatic memories. Expand
Stability of recent and remote contextual fear memory.
TLDR
Reconolidation of contextual fear memory in mice and the dissociation between the effects of systemically and centrally administered ANI on remote memory suggests that stability is due, in part, to the distributed nature of remote contextual fear memories. Expand
Neuronal circuits of fear extinction
TLDR
Emerging concepts of the neuronal circuitry of fear extinction are reviewed, and novel findings suggesting that the fragile phenomenon of extinction can be converted into a permanent erasure of fear memories are highlighted. Expand
Engrams and circuits crucial for systems consolidation of a memory
TLDR
It is found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal–entorhinal cortex network and the basolateral amygdala. Expand
A temporal shift in the circuits mediating retrieval of fear memory
TLDR
It is shown that the dorsal midline thalamus of rats is required for the retrieval of auditory conditioned fear at late, but not early, time points after learning, and the PVT may act as a crucial thalamic node recruited into cortico-amygdalar networks for retrieval and maintenance of long-term fear memories. Expand
Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear.
TLDR
Pavlovian fear conditioning as a model and the amygdala as a key component for the acquisition and extinction of fear responses are focused on. Expand
Fear Conditioning and Extinction Differentially Modify the Intrinsic Excitability of Infralimbic Neurons
TLDR
IL intrinsic excitability is reduced to allow forexpression of conditioning memory and enhanced for expression of extinction memory through the modulation of Ca2+-gated K+ channels underlying the slow afterhyperpolarizing potential (sAHP). Expand
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