Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex

@article{Pizzorusso2002ReactivationOO,
  title={Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex},
  author={T. Pizzorusso and P. Medini and N. Berardi and S. Chierzi and J. Fawcett and L. Maffei},
  journal={Science},
  year={2002},
  volume={298},
  pages={1248 - 1251}
}
  • T. Pizzorusso, P. Medini, +3 authors L. Maffei
  • Published 2002
  • Biology, Medicine
  • Science
  • In young animals, monocular deprivation leads to an ocular dominance shift, whereas in adults after the critical period there is no such shift. Chondroitin sulphate proteoglycans (CSPGs) are components of the extracellular matrix (ECM) inhibitory for axonal sprouting. We tested whether the developmental maturation of the ECM is inhibitory for experience-dependent plasticity in the visual cortex. The organization of CSPGs into perineuronal nets coincided with the end of the critical period and… CONTINUE READING
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