Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties.

@article{Buzhor2013ReactivationON,
  title={Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties.},
  author={Ella Buzhor and Dorit Omer and Orit Harari-Steinberg and Zohar A. Dotan and Einav Vax and S Pri-chen and Sally Metsuyanim and Oren Pleniceanu and Ronald S Goldstein and Benjamin Dekel},
  journal={The American journal of pathology},
  year={2013},
  volume={183 5},
  pages={1621-1633}
}
The nephron is composed of a monolayer of epithelial cells that make up its various compartments. In development, these cells begin as mesenchyme. NCAM1, abundant in the mesenchyme and early nephron lineage, ceases to express in mature kidney epithelia. We show that, once placed in culture and released from quiescence, adult human kidney epithelial cells (hKEpCs), uniformly positive for CD24/CD133, re-express NCAM1 in a specific cell subset that attains a stem/progenitor state. Immunosorted… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…