Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates

  title={Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates},
  author={Franz Worek and Georg Reiter and Peter Eyer and Ladislaus Szinicz},
  journal={Archives of Toxicology},
Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sarin. In the past decades numerous oximes were prepared and tested for their efficacy in OP poisoning, mostly in animal experiments. However, data indicate that the reactivating… CONTINUE READING


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