Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma.

@article{Monini1999ReactivationAP,
  title={Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma.},
  author={Paolo Monini and Sandra Colombini and Michael St{\"u}rzl and Delia Goletti and Aurelio Cafaro and Cecilia Sgadari and Stefano Butt{\'o} and Marina Franco and Stefano Fais and Patrizia Leone and Gianna Melucci-Vigo and Chiara Chiozzini and Francesca Carlini and Gudrun Ascherl and Emmanuelle Cornali and Christian Zietz and Eric Ramazzotti and Fabrizio Ensoli and Massimo Andreoni and Patrizio Pezzotti and Giovanni Rezza and Robert Yarchoan and Robert C. Gallo and Barbara Ensoli},
  journal={Blood},
  year={1999},
  volume={93 12},
  pages={4044-58}
}
Patients with Kaposi's sarcoma (KS) have a human herpesvirus-8 (HHV-8) load higher than patients without KS and present a CD8(+) T-cell activation with production of Th1-type cytokines both in tissues and peripheral blood mononuclear cells (PBMC). Because in tissues of KS patients detection of inflammatory cytokines (IC) can precede detection of HHV-8 DNA and because signs of immunoactivation and/or dysregulation can precede KS development, we investigated the effect of IC on HHV-8 infection… CONTINUE READING