Reactivated herpes simplex infection increases the risk of Alzheimer's disease

@article{Lvheim2015ReactivatedHS,
  title={Reactivated herpes simplex infection increases the risk of Alzheimer's disease},
  author={Hugo L{\"o}vheim and Jonathan D Gilthorpe and Rolf Adolfsson and Lars G. Nilsson and Fredrik Elgh},
  journal={Alzheimer's \& Dementia},
  year={2015},
  volume={11},
  pages={593-599}
}
Previous studies have suggested a link between herpes simplex virus (HSV) type 1 and the development of Alzheimer's disease (AD). 
Herpes simplex infection and the risk of Alzheimer's disease: A nested case-control study
Herpes simplex virus (HSV) is thought to play an etiological role in the development of Alzheimer's disease (AD).
Interaction between APOE4 and herpes simplex virus type 1 in Alzheimer's disease
TLDR
Numerous results suggest the implication of infectious agents in the onset of Alzheimer's disease (AD) and the role of these agents is still under investigation.
A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's disease
Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis.
Herpesvirus Infection and Immunity in Neurocognitive Disorders
Herpesviruses have co-speciated with several vertebrate and invertebrate animals throughout the history of evolution. In the immunocompetent human host, primary infection is usually benign, whereaf
Microbes and Alzheimer's Disease.
TLDR
Researchers and clinicians working on Alzheimer’s disease or related topics write to express their concern that one particular aspect of the disease has been neglected.
The Association Between Herpes Simplex Virus Type 1 Reactivation and Alzheimer’s Disease
This review will focus on the interaction of herpes simplex virus type 1 (HSV-1) and its causative role in pathogenesis of Alzheimer’s disease (AD) noting specifically, the epidemiological relevance
The viral hypothesis: how herpesviruses may contribute to Alzheimer’s disease
TLDR
It is suggested that many of the hallmarks of AD, like amyloid beta production and neuroinflammation, can arise as a protective response to acute infection that becomes maladaptive in the case of chronic infection.
The Potential Role of Herpes Simplex Virus Type 1 and Neuroinflammation in the Pathogenesis of Alzheimer's Disease
TLDR
Current work on the pathogenesis of AD is discussed and research results that support a potential role for HSV1 in the infectious hypothesis of AD are summarized and some of the contradictory data and remaining knowledge gaps are pointed out.
Interaction between Cytomegalovirus and Herpes Simplex Virus Type 1 Associated with the Risk of Alzheimer's Disease Development.
TLDR
CMV infection facilitates the development of HSV1-associated AD, possibly via its effects on the immune system, and an interaction between CMV and HSV 1 was found to be associated significantly with AD development.
Herpes and Alzheimer's Disease: Subversion in the Central Nervous System and How It Might Be Halted.
  • R. Itzhaki
  • Medicine
    Journal of Alzheimer's disease : JAD
  • 2016
TLDR
All the studies support the usage of antiviral treatment to slow or halt the progression of AD and the role specifically of HSV1 and its reactivation in the disease.
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It is reported that an internal sequence of HSV1 glycoprotein B is homologous to the carboxyl-terminal region of the Aβ peptide that accumulates in diffuse and neuritic plaques in AD.
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