Reactions of the Wurster's blue radical cation with thiols, and some properties of the reaction products.

@article{Strle1991ReactionsOT,
  title={Reactions of the Wurster's blue radical cation with thiols, and some properties of the reaction products.},
  author={Christian St{\"o}rle and Peter Eyer},
  journal={Chemico-biological interactions},
  year={1991},
  volume={78 3},
  pages={
          333-46
        }
}
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Reactions of oxidatively activated arylamines with thiols: reaction mechanisms and biologic implications. An overview.
  • P. Eyer
  • Chemistry, Biology
    Environmental health perspectives
  • 1994
TLDR
Interactions of activated arylamines with thiols may not be regarded exclusively as detoxication reactions, and examples of toxicologic implications of the interactions of nitroso compounds withThiols are given.
Bioactivation of thiols by one-electron oxidation.
  • R. Munday
  • Biology, Chemistry
    Advances in pharmacology
  • 1994
Reactions of the wurster's red radical cation with hemoglobin and glutathione during the cooxidation of N,N-dimethyl-p-phenlenediamine and oxyhemoglobin in human red cells
Structural requirements for the ferrihemoglobin-forming activity of glutathione S-conjugates of 4-dimethylaminophenol.
TLDR
Ferrihemoglobin-forming activity was investigated with oxyhemoglobin, alkylated with N-ethylmaleimide (Hb-NES) to prevent binding of oxidized compounds to the protein SH groups and the same thioether reactivity was observed during autoxidation.
Quantitative determination by ESR of the arylaminyl free radical during the reaction of N,N,N',N'-tetramethyl-p-phenylenediamine with oxyhemoglobin.
TLDR
The results indicate that erythrocytes may play a critical role in activation and detoxication of p-phenylenediamines and quenching of the radicals by ferrohemoglobin to protect cellular thiols will be effective as long as the capacity of the methemoglobin reductase system is not overwhelmed.
QUANTITATIVE DETERMINATION BY ESR OF THE ARYLAMINYL FREE RADICAL DURING PHENYLENEDIAMINE WITH OXYHEMOGLOBIN THE REACTION OF N,N,N',N'-TETRAMETHYL-p-
TLDR
The results indicate that erythrocytes may play a critical role in activation and detoxication of p-phenylenediarnines and quenching of the radicals by ferrohemoglobin to protect cellular thiols will be effective as long as the capacity of the methemoglobin reductase system is not overwhelmed.
Chemical mechanisms for skin sensitization by aromatic compounds with hydroxy and amino groups.
TLDR
A molecular mechanism to rationalize the sensitization potential of aromatic diamino-, dihydroxy-, and amino-hydroxy compounds is presented and the results of quantum mechanics calculations show how this mechanism can explain observed structure-potency trends.
Tetramethylphenylenediamine-induced hepatocyte cytotoxicity caused by lysosomal labilisation and redox cycling with oxygen activation.
Phenylenediamine induced hepatocyte cytotoxicity redox. Cycling mediated oxidative stress without oxygen activation.
Free Radical Metabolites in Arylamine Toxicity
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