Reactions of peroxynitrite in the mitochondrial matrix.

  title={Reactions of peroxynitrite in the mitochondrial matrix.},
  author={Laura Beatriz Valdez and Silvia {\'A}lvarez and Silvia Lores Arnaiz and Francisco J Sch{\"o}pfer and Mar{\'i}a Cecilia Carreras and Juan Jos{\'e} Poderoso and Alberto E Boveris},
  journal={Free radical biology & medicine},
  volume={29 3-4},
Superoxide radical (O2-) and nitric oxide (NO) produced at the mitochondrial inner membrane react to form peroxynitrite (ONOO-) in the mitochondrial matrix. Intramitochondrial ONOO- effectively reacts with a few biomolecules according to reaction constants and intramitochondrial concentrations. The second-order reaction constants (in M(-1) s(-1)) of ONOO- with NADH (233 +/- 27), ubiquinol-0 (485 +/- 54) and GSH (183 +/- 12) were determined fluorometrically by a simple competition assay of… CONTINUE READING
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