Reactions of cyanomethylbenzimidazoles. Part IV. Derivatives of 2-[alpha-cyano-beta-aryl-(dialkyl)-vinyl]-benzimidazole and N-arylthioamides of benzimidazolyl-2-alpha-cyanoacetic acid and their tuberculostatic activity.
Several derivatives of N-arylthioamide of benzimidazolyl-2-alpha-cyanoacetic acid and 2-(alpha-cyano-beta-chlorophenyl)-benzimidazole and its 4(7)- and 5(6)-methyl derivatives have been obtained. Tuberculostatic activity of these compounds was determined on the Mycobacterium tuberculosis H37Rv strain. LD50 values were determined for derivatives of 2-(alpha… (More)