Reaction phenotyping: advances in the experimental strategies used to characterize the contribution of drug-metabolizing enzymes.

@article{Zientek2015ReactionPA,
  title={Reaction phenotyping: advances in the experimental strategies used to characterize the contribution of drug-metabolizing enzymes.},
  author={Michael A. Zientek and Kuresh A Youdim},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2015},
  volume={43 1},
  pages={163-81}
}
During the process of drug discovery, the pharmaceutical industry is faced with numerous challenges. One challenge is the successful prediction of the major routes of human clearance of new medications. For compounds cleared by metabolism, accurate predictions help provide an early risk assessment of their potential to exhibit significant interpatient differences in pharmacokinetics via routes of metabolism catalyzed by functionally polymorphic enzymes and/or clinically significant metabolic… CONTINUE READING

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