Reaction of nitric oxide with superoxide inhibits basolateral K+ channels in the rat CCD.

@article{Lu1998ReactionON,
  title={Reaction of nitric oxide with superoxide inhibits basolateral K+ channels in the rat CCD.},
  author={Ming Liang Lu and Wenhui Wang},
  journal={American journal of physiology. Cell physiology},
  year={1998},
  volume={275 1},
  pages={C309-C316}
}
We previously demonstrated that nitric oxide (NO) stimulates the basolateral small-conductance K+channel (SK) via a cGMP-dependent pathway [M. Lu and W. H. Wang. Am. J. Physiol. 270 ( Cell Physiol. 39): C1336-C1342, 1996]. Because NO at high concentration has been shown to react with superoxide ([Formula: see text]) to form peroxynitrite (OONO-) [W. A. Pryor and G. L. Squadrito. Am. J. Physiol. 268 ( Lung Cell. Mol. Physiol. 12): L699-L722, 1995 and M. S. Wolin. Microcirculation 3: 1-17, 1996… CONTINUE READING
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