Reaction of nitric oxide with superoxide inhibits basolateral K+ channels in the rat CCD.

  title={Reaction of nitric oxide with superoxide inhibits basolateral K+ channels in the rat CCD.},
  author={Ming Liang Lu and Wenhui Wang},
  journal={American journal of physiology. Cell physiology},
  volume={275 1},
We previously demonstrated that nitric oxide (NO) stimulates the basolateral small-conductance K+channel (SK) via a cGMP-dependent pathway [M. Lu and W. H. Wang. Am. J. Physiol. 270 ( Cell Physiol. 39): C1336-C1342, 1996]. Because NO at high concentration has been shown to react with superoxide ([Formula: see text]) to form peroxynitrite (OONO-) [W. A. Pryor and G. L. Squadrito. Am. J. Physiol. 268 ( Lung Cell. Mol. Physiol. 12): L699-L722, 1995 and M. S. Wolin. Microcirculation 3: 1-17, 1996… CONTINUE READING
19 Extracted Citations
37 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 19 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 37 references

Protein kinase C modulates calcium sensitivity of nitric oxide synthase in cerebellar slices

  • D. Okada
  • J. Neurochem
  • 1995
Highly Influential
9 Excerpts

Effects of sodium nitroprusside in the rat cortical collecting duct are independent of the NO pathway

  • J. R. Hirsch, R. Cermak, +6 authors E. Schlatter
  • Kidney Int
  • 1997
3 Excerpts

Koppenol . Nitric oxide , superoxide , and peroxynitrite : the good , the bad , and the ugly

  • J. S. Beckman, H. W.
  • Am . J . Physiol . 271 ( Cell Physiol .
  • 1996

Similar Papers

Loading similar papers…