Reaction of germinal centers in the T-cell-independent response to the bacterial polysaccharide alpha(1-->6)dextran.

@article{Wang1994ReactionOG,
  title={Reaction of germinal centers in the T-cell-independent response to the bacterial polysaccharide alpha(1-->6)dextran.},
  author={Denong Wang and Shannon M. Wells and Alan M. Stall and Elvin A. Kabat},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 7},
  pages={2502-6}
}
Primary immunization of BALB/c mice with alpha(1-->6)dextran (DEX), a native bacterial polysaccharide, induces an unexpected pattern of splenic B-cell responses. After a peak of antibody-secreting B-cell response at day 4, deposition of dextran-anti-dextran immune complexes, as revealed by staining with both dextran and antibodies to dextran, occurs and persists in splenic follicles until at least the fourth week after immunization. Antigen-specific B cells appear and proliferate in such… CONTINUE READING

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