Reaction of dehydroascorbic acid with unithiol and some of its kinetic regularities

Abstract

Many compounds containing the thio group are proposed as ascorbic acid (AA) stabilizers in prepared medicinal forms: cysteine, thiourea, methylthiouracil, glutathione, etc. [i, 2]. Recently it was shown that introduction of sodium 2,3-dimercaptopropanesulfonate (unithiol) into injection solutions of ~ strongly retards the development of coloration of the latter that appears upon lengthy storing of the ampuls [3, 4]. Darkening of the solution is caused by impurities of polymeric-type materials, which are formed upon oxidative decomposition of AA. In all probability the mechanism of stabilization by unithiol is based, on one hand, on its extraordinarily easy capability for oxidation [5], which leads to bonding of available oxygen in the ampul, and on the other hand, on the property of unithiol to form complexes with heavy metal ions [6], catalyzing decomposition of AA. As we have shown, it is also necessary to consider the ability of unithiol to reduce reversibly and easily the primary oxidation product of AA, dehydroascorbic acid (DAA). This paper is devoted to the study of reaction of DAAwith unithiol as a result of which AA is formed.

DOI: 10.1007/BF00757696

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Cite this paper

@article{Kozlov2004ReactionOD, title={Reaction of dehydroascorbic acid with unithiol and some of its kinetic regularities}, author={Evgenii Kozlov and M. Sh. L'vova}, journal={Pharmaceutical Chemistry Journal}, year={2004}, volume={10}, pages={643-648} }