Reaction of biological phenolic antioxidants with superoxide generated by cytochrome P-450 model system.

Abstract

Scavenging of a superoxide and simultaneous formation of free radicals with phenolic antioxidants were investigated with cobalt and iron tetraphenylporphyrin-thiolate complexes as models of P-450 enzymes. The kinetics of decay of the superoxide and development of free radical ESR signal intensities were studied. Based on a molecular orbital calculation of the hyperfine splitting, the radical species generated were confirmed to be those of phenoxyl radicals. The biological implication of superoxide, including active oxygen forms, for the reaction was discussed.

Statistics

0200400600'89'92'95'98'01'04'07'10'13'16
Citations per Year

451 Citations

Semantic Scholar estimates that this publication has 451 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Tajima1983ReactionOB, title={Reaction of biological phenolic antioxidants with superoxide generated by cytochrome P-450 model system.}, author={Kazuo Tajima and Maya Sakamoto and Kenji Okada and Kiyoshi Mukai and Ken-ichiro Ishizu and Hiroyuki Sakurai and Hiroki Mori}, journal={Biochemical and biophysical research communications}, year={1983}, volume={115 3}, pages={1002-8} }