Corpus ID: 97593449

Reaction of 3-Hydroxykynurenine with lens proteins and synthetic peptides

@inproceedings{Aquilina2000ReactionO3,
  title={Reaction of 3-Hydroxykynurenine with lens proteins and synthetic peptides},
  author={J. A. Aquilina},
  year={2000}
}
3-Hydroxykynurenine (30HKyn), present in the human lens as a UV-filter, is a powerful antioxidant which has also been implicated as a carcinogen and neurotoxin. The neurotoxicity results from the oxidation of30HKyn due to the formation ofH202 and possibly hydroxyl radicals. Oxidation of o-aminophenols, such as 30HKyn, also results in the formation of highly reactive quinonimines. Thus one possible consequence of30HKyn oxidation may be the covalent modification of cellular macromolecules. Such a… Expand
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