Reaction mechanism of oxidative rearrangement of flavanone in isoflavone biosynthesis.

  title={Reaction mechanism of oxidative rearrangement of flavanone in isoflavone biosynthesis.},
  author={Mir Hashim and Takashi Hakamatsuka and Yutaka Ebizuka and Ushio Sankawa},
  journal={FEBS letters},
  volume={271 1-2},
Microsomes that were prepared from elicitor-treated Pueraria lobata cell cultures catalyzed the conversion of liquiritigenin, a flavanone, into daidzein, an isoflavone. The reaction was resolved into two steps. 2, 7, 4'-Trihydroxyisoflavonone was formed as a major product when liquiritigenin was incubated with carefully washed microsomes in the presence of NADPH. The structure of 2, 7, 4'-trihydroxyisoflavanone was confirmed by mass and 1H NMR spectroscopies. The enzyme responsible for this… CONTINUE READING
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