Reaction mechanism of gramicidin S synthetase 1, phenylalanine racemase, of Bacillus brevis.

@article{Kanda1989ReactionMO,
  title={Reaction mechanism of gramicidin S synthetase 1, phenylalanine racemase, of Bacillus brevis.},
  author={M. Kanda and K. Hori and T. Kurotsu and S. Miura and Y. Saito},
  journal={Journal of biochemistry},
  year={1989},
  volume={105 4},
  pages={
          653-9
        }
}
  • M. Kanda, K. Hori, +2 authors Y. Saito
  • Published 1989
  • Biology, Medicine
  • Journal of biochemistry
  • We have demonstrated that gramicidin S synthetase 1 (GS 1), phenylalanine racemase [EC 5.1.1.11], of Bacillus brevis catalyzes the exchange between a proton in the medium and alpha-hydrogen of phenylalanine in the course of the racemase reaction by using tritiated water or L-phenyl[2,3-3H]alanine. GS 1 from some gramicidin S non-producing mutants of B. brevis lacking phenylalanine racemase activity did not catalyze the tritium exchange reaction. The proton exchange between phenylalanine bound… CONTINUE READING
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