Reaction engineering studies for the production of 2-hydroxyisobutyric acid with recombinant Cupriavidus necator H 16

@article{Hoefel2010ReactionES,
  title={Reaction engineering studies for the production of 2-hydroxyisobutyric acid with recombinant Cupriavidus necator H 16},
  author={Torben Hoefel and E. J. Wittmann and Liv Reinecke and Dirk Weuster-Botz},
  journal={Applied Microbiology and Biotechnology},
  year={2010},
  volume={88},
  pages={477-484}
}
Recombinant Cupriavidus necator H 16 with a novel metabolic pathway using a cobalamin-dependent mutase was exploited to produce 2-hydroxyisobutyric acid (2-HIBA) from renewable resources through microbial fermentation. 2-HIBA production capacities of different strains of C. necator H 16 deficient in the PHB synthase gene and genetically engineered to enable the production of 2-HIBA from the intracellular PHB precursor (R)-3-hydroxybutyryl-CoA were evaluated in 48 parallel milliliter-scale… CONTINUE READING
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Genome sequence of the PHA-Producing “Knallgas” bacterium Ralstonia eutropha H16: analysis with regard to PHA Metabolism

  • F Reinecke
  • 2007
Highly Influential
9 Excerpts

Verwendung eines zu einem MeaB-Protein homologen Proteins zur Erhöhung der enzymatischen Aktivität einer 3-Hydroxycarbonsäure-CoA-Mutase

  • L Reinecke, A Thiessenhusen, S Schaffer, M Buchhaupt, T Köhler, A Marx
  • 2010
Highly Influential
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Mass production of poly(3-hydroxybutyrate) by fed-batch cultures of Ralstonia eutropha with nitrogen and phosphate limitation

  • HW Ryu, KS Cho, BS Kim, YK Chang, HN Chang, HJ Shim
  • J Microbiol Biotechnol
  • 1999
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