Reaction engineering analysis of L-lysine transport by Corynebacterium glutamicum.

  title={Reaction engineering analysis of L-lysine transport by Corynebacterium glutamicum.},
  author={Ralf Kelle and Birgit Laufer and C Brunzema and Dirk Weuster-Botz and R. Andreas Kraemer and Christian Wandrey},
  journal={Biotechnology and bioengineering},
  volume={51 1},
To identify potential L-lysine export limitations by Corynebacterium glutamicum in the L-lysine production process, the excretion of L-lysine was studied in continuous and fed-batch operated stirred tank reactors. A structured biochemical model of the L-lysine excretion mechanism was used to determine the activity of the export carrier and to calculate a cell-specific concentration of the export carrier. For the biochemical characterization of this specific carrier concentration a standardized… CONTINUE READING

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