Reaction-based fluorescent sensor for investigating mobile Zn2+ in mitochondria of healthy versus cancerous prostate cells.

@article{Chyan2014ReactionbasedFS,
  title={Reaction-based fluorescent sensor for investigating mobile Zn2+ in mitochondria of healthy versus cancerous prostate cells.},
  author={Wen Chyan and Daniel Yue Zhang and Stephen J Lippard and Robert J. Radford},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 1},
  pages={143-8}
}
Chelatable, mobile forms of divalent zinc, Zn(II), play essential signaling roles in mammalian biology. A complex network of zinc import and transport proteins has evolved to control zinc concentration and distribution on a subcellular level. Understanding the action of mobile zinc requires tools that can detect changes in Zn(II) concentrations at discrete cellular locales. We present here a zinc-responsive, reaction-based, targetable probe based on the diacetyled form of Zinpyr-1. The compound… CONTINUE READING
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Selective mitochondrial staining with small fluorescent probes: Importance, design, synthesis, challenges and trends for new markers

  • BAD Neto, JR Corrêa, RG Silva
  • RSC Adv
  • 2013

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