Reaching out for signals

  title={Reaching out for signals},
  author={Diane S. Lidke and Keith A. Lidke and Bernd Rieger and Thomas M. Jovin and Donna J. Arndt-Jovin},
  journal={The Journal of Cell Biology},
  pages={619 - 626}
ErbB1 receptors situated on cellular filopodia undergo systematic retrograde transport after binding of the epidermal growth factor (EGF) and activation of the receptor tyrosine kinase. Specific inhibitors of the erbB1 receptor tyrosine kinase as well as cytochalasin D, a disruptor of the actin cytoskeleton, abolish transport but not free diffusion of the receptor-ligand complex. Diffusion constants and transport rates were determined with single molecule sensitivity by tracking receptors… CONTINUE READING


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