Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

@article{Wells2007ReachingFH,
  title={Reaching for high-hanging fruit in drug discovery at protein–protein interfaces},
  author={James A. Wells and Christopher L. McClendon},
  journal={Nature},
  year={2007},
  volume={450},
  pages={1001-1009}
}
Targeting the interfaces between proteins has huge therapeutic potential, but discovering small-molecule drugs that disrupt protein–protein interactions is an enormous challenge. Several recent success stories, however, indicate that protein–protein interfaces might be more tractable than has been thought. These studies discovered small molecules that bind with drug-like potencies to 'hotspots' on the contact surfaces involved in protein–protein interactions. Remarkably, these small molecules… 
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