ReN-1869 [(R)-1-(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine Carboxylic Acid], a Novel Histamine H1 Receptor Antagonist, Produces Potent and Selective Antinociceptive Effects on Dorsal Horn Neurons after Inflammation and Neuropathy
@article{Suzuki2004ReN1869C, title={ReN-1869 [(R)-1-(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine Carboxylic Acid], a Novel Histamine H1 Receptor Antagonist, Produces Potent and Selective Antinociceptive Effects on Dorsal Horn Neurons after Inflammation and Neuropathy}, author={Rie Suzuki and Martin Edwards and A. H. Dickenson}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2004}, volume={309}, pages={1230 - 1238} }
We characterized the effect of a novel selective histamine H1 receptor antagonist, (R)-1-(3-(10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5-ylidene)-1-propyl)-3-piperidine carboxylic acid (ReN-1869), on the responses of dorsal horn neurons in anesthetized rats after carrageenan induced-inflammation and peripheral neuropathy (L5/6 spinal nerve ligation; SNL). ReN-1869 was administered systemically (0.1-4 mg/kg), and drug effects were assessed using a wide range of peripheral electrical and natural…
4 Citations
NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin
- BiologyPAIN
- 2008
Differential pharmacological modulation of the spontaneous stimulus-independent activity in the rat spinal cord following peripheral nerve injury
- Biology, PsychologyExperimental Neurology
- 2006
Central nervous system mast cells in peripheral inflammatory nociception
- Biology, MedicineMolecular pain
- 2011
It is suggested that lumbar dural mast cells may be sufficient but are not necessary for capsaicin or carrageenan-induced hyperalgesia.
Facile One-Pot Synthesis of 1,2,3,4-Tetrahydroquinoline-3-carboxylic Acids and Their Heterocyclic Analogs
- Chemistry
- 2008
Abstract A facile one-pot method for the synthesis of 1,2,3,4-tetrahydroquinoline-3-carboxylic acids and their heterocyclic analogs based on the tert-amino effect. A set of…
References
SHOWING 1-10 OF 41 REFERENCES
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.
- BiologyEuropean journal of pharmacology
- 2002
The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception
- BiologyNeuroscience
- 2001
Evidence for hypernociception induction following histamine H1 receptor activation in rodents.
- BiologyLife sciences
- 1998
The in vivo pharmacological profile of histamine (H1) antagonists in the rat
- Biology, Chemistry
- 1982
Astemizole, ketotifen, and terfenadine were found to be very specific H1‐antagonists and Sedative effects of H1-antagonists were not detected by the pharmacological tests used here.
Effects of intrathecally injected histamine receptor antagonists on the antinociception induced by morphine, β-endorphin, and U50, 488H administered intrathecally in the mouse
- Biology, ChemistryNeuropeptides
- 1996
The differential effects of histamine receptor antagonists on morphine- and U-50,488H-induced antinociception in the mouse.
- BiologyLife sciences
- 1994
Gene expression of histamine H1 receptor in guinea pig primary sensory neurons: a relationship between H1 receptor mRNA-expressing neurons and peptidergic neurons.
- BiologyBrain research. Molecular brain research
- 1999
Role of histamine H1 receptor in pain perception: a study of the receptor gene knockout mice
- Biology
- 2000
The Effects of Pyrilamine and Cimetidine on mRNA C-Fos Expression and Nociceptive Flinching Behavior in Rats
- BiologyAnesthesia and analgesia
- 2003
C-fos and Fos expression, frequently used as a neural nociceptive marker, is altered by many drugs. The effects of histamine receptor antagonists on c-fos messenger (m)RNA expression are unknown. We…
Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis
- Medicine, BiologyPain
- 1997